Erbb2^{tm6(Erbb2)Mul}
Targeted Allele Detail

Summary

• Symbol: Erbb2^{tm6(Erbb2)Mul}
• Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 6, William J Muller
• MGI ID: MGI:3521859
• Synonyms: Erbb2^Y1144F
• Gene: Erbb2 Location: Chr11:98303310-98328542 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Erbb2^{tm6(Erbb2)Mul} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94397
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to replace the first coding exon with the rat Erbb2 cDNA with the Y1144F mutation, resulting in the loss of the direct binding site for Grb2. A neo was also inserted. Analysis of the RT-PCR product indicated that mutants only expressed the rat cDNA. (J:94397)

Expression

In Mice Carrying this Mutation:

7 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb2 Mutation: 61 strains or lines available

References

• Original: J:94397 Chan R, et al., Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development. Development. 2004 Nov;131(22):5551-60
• All: 1 reference(s)