Erbb2^{tm7(Erbb2)Mul}
Targeted Allele Detail

Summary

• Symbol: Erbb2^{tm7(Erbb2)Mul}
• Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 7, William J Muller
• MGI ID: MGI:3521860
• Synonyms: Erbb2^Y1227F
• Gene: Erbb2 Location: Chr11:98303310-98328542 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Erbb2^{tm7(Erbb2)Mul} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94397
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Erbb2^{tm7(Erbb2)Mul} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Erbb2 (24337)

  Erbb2

  (MGI:95410)

  Expresses rat Erbb2 cDNA with a Y1227F mutation

• Mutation details: A targeting vector was designed to replace the first coding exon with the rat Erbb2 cDNA with the Y1227F mutation, resulting in the loss of the direct binding site for Shc1. A neo was also inserted. Analysis of the RT-PCR product indicated that mutants only expressed the rat cDNA. (J:94397)

Expression

In Mice Carrying this Mutation:

7 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb2 Mutation: 61 strains or lines available

References

• Original: J:94397 Chan R, et al., Modulation of Erbb2 signaling during development: a threshold level of Erbb2 signaling is required for development. Development. 2004 Nov;131(22):5551-60
• All: 1 reference(s)