Serpini2^pq
Transgenic Allele Detail

Summary

• Symbol: Serpini2^pq
• Name: serine (or cysteine) peptidase inhibitor, clade I, member 2; pequeno
• MGI ID: MGI:3521922
• Gene: Serpini2 Location: Chr3:75149677-75177385 bp, - strand Genetic Position: Chr3, 33.74 cM
• Alliance: Serpini2^pq page

Runted size and acinar cell loss in Serpini2^pq/Serpini2^pq mice

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic
• Mutation: Intergenic deletion
• Mutation details: Random transgene insertion leading to an approximately 210-kb deletion which includes the entire Serpini2 gene and several 3' exons of Ensembl-predicted novel gene transcript sequences ENSMUST00000062199.1 and ENSMUST00000038943.1. BAC transgene complementation demonstrated that Serpini2 deletion is responsible for the phenotype. (J:115744)

Disease models

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serpini2 Mutation: 20 strains or lines available

References

• Original: J:115744 Loftus SK, et al., Acinar cell apoptosis in Serpini2-deficient mice models pancreatic insufficiency. PLoS Genet. 2005 Sep;1(3):e38
• All: 1 reference(s)