Top2b^tm2.1Jcw
Targeted Allele Detail

Summary

• Symbol: Top2b^tm2.1Jcw
• Name: topoisomerase (DNA) II beta; targeted mutation 2.1, James C Wang
• MGI ID: MGI:3521923
• Synonyms: top2beta^delta2
• Gene: Top2b Location: Chr14:6038976-6104585 bp, - strand Genetic Position: Chr14, 7.08 cM, cytoband A3
• Alliance: Top2b^tm2.1Jcw page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94879
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The floxed region was excised from Top2b^tm2Jcw by crossing to mice carrying Tg(PRM-Cre)58Og. (J:94879)

Expression

In Mice Carrying this Mutation:	59 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Top2b Mutation: 91 strains or lines available

References

• Original: J:94879 Lyu YL, et al., Aberrant lamination in the cerebral cortex of mouse embryos lacking DNA topoisomerase IIbeta. Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7123-8
• All: 7 reference(s)