Mmp13^tm1.1Werb
Targeted Allele Detail

Summary

• Symbol: Mmp13^tm1.1Werb
• Name: matrix metallopeptidase 13; targeted mutation 1.1, Zena Werb
• MGI ID: MGI:3521938
• Synonyms: Mmp13^-
• Gene: Mmp13 Location: Chr9:7272514-7283331 bp, + strand Genetic Position: Chr9, 2.46 cM, cytoband A1-A2
• Alliance: Mmp13^tm1.1Werb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94460
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3-5 were replaced with a single loxP site following homologous recombination and subsequent Cre-mediated excision of the floxed segment. Western blot showed that no protein was created in the mutant mice. (J:94460)

Expression

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mmp13 Mutation: 36 strains or lines available

References

• Original: J:94460 Stickens D, et al., Altered endochondral bone development in matrix metalloproteinase 13-deficient mice. Development. 2004 Dec;131(23):5883-95
• All: 11 reference(s)