Cacng4^tm1Frk
Targeted Allele Detail

Summary

• Symbol: Cacng4^tm1Frk
• Name: calcium channel, voltage-dependent, gamma subunit 4; targeted mutation 1, Wayne N Frankel
• MGI ID: MGI:3521945
• Synonyms: g4tml
• Gene: Cacng4 Location: Chr11:107623183-107685383 bp, - strand Genetic Position: Chr11, 70.29 cM, cytoband E1
• Alliance: Cacng4^tm1Frk page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96506
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A lacZ gene was inserted in frame into exon 4 of the gene. A fusion protein consisting of part of Cacng4 and beta-galactosidase is expressed from this allele. (J:96506)

Expression

In Mice Carrying this Mutation:

17 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cacng4 Mutation: 15 strains or lines available

References

• Original: J:96506 Letts VA, et al., A targeted mutation in Cacng4 exacerbates spike-wave seizures in stargazer (Cacng2) mice. Proc Natl Acad Sci U S A. 2005 Feb 8;102(6):2123-8
• All: 1 reference(s)