Dll4^tm1Nwg
Targeted Allele Detail

Summary

• Symbol: Dll4^tm1Nwg
• Name: delta like canonical Notch ligand 4; targeted mutation 1, Nicholas W Gale
• MGI ID: MGI:3521976
• Synonyms: Dll4^lacZ, Dll4^Lz
• Gene: Dll4 Location: Chr2:119156286-119166145 bp, + strand Genetic Position: Chr2, 59.97 cM, cytoband E3
• Alliance: Dll4^tm1Nwg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94740
• Parent Cell Line: F1H4 (ES Cell)
• Strain of Origin: (129S6/SvEvTac x C57BL/6NTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replaced with a Beta-gal neo cassette. Quantitative PCR indicated that transcript levels in heterozygotes were decreased compared to wild-type transcript levels. (J:94740)

Expression

In Structures Affected by this Mutation:

10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dll4 Mutation: 27 strains or lines available

References

• Original: J:94740 Gale NW, et al., Haploinsufficiency of delta-like 4 ligand results in embryonic lethality due to major defects in arterial and vascular development. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):15949-54
• All: 7 reference(s)