Del(11Cops3-Rnf112)1Jrl
Targeted Allele Detail

Summary

• Symbol: Del(11Cops3-Rnf112)1Jrl
• Name: deletion, Chr 11, James R Lupski 1
• MGI ID: MGI:3521985
• Synonyms: Del(11Csn3-Zfp179)1Jrl, Del1Jrl, df(11)17
• Gene: Del(11Cops3-Rnf112)1Jrl Location: Chr11:59708621-61344957 bp Genetic Position: Chr11, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:83302
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Intergenic deletion, Intragenic deletion
• Del(11Cops3-Rnf112)1Jrl involves 77 genes/genome features (Gm24945, Gm26837, Gm27511 ...) View all
• Mutation details: A deletion between Cops3 and Rnf112 was engineered in ES cells by targeted insertion of complementary partial Hprt-loxP constructs at each site. Cre recombinase actived deleted the intervening region and reconstructed the Hprt minigene for selection purposes. (J:83302)

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Del(11Cops3-Rnf112)1Jrl Mutation: 1 strain or line available

References

• Original: J:83302 Walz K, et al., Modeling del(17)(p11.2p11.2) and dup(17)(p11.2p11.2) contiguous gene syndromes by chromosome engineering in mice: phenotypic consequences of gene dosage imbalance. Mol Cell Biol. 2003 May;23(10):3646-55
• All: 8 reference(s)