Hes3^tm1Kag
Targeted Allele Detail

Summary

• Symbol: Hes3^tm1Kag
• Name: hes family bHLH transcription factor 3; targeted mutation 1, Ryoichiro Kageyama
• MGI ID: MGI:3521989
• Synonyms: Hes3^-
• Gene: Hes3 Location: Chr4:152370429-152376119 bp, - strand Genetic Position: Chr4, 83.01 cM
• Alliance: Hes3^tm1Kag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:71074
• Parent Cell Line: TT2 (ES Cell)
• Strain of Origin: (C57BL/6NCrlj x CBA/JNCrlj)F1

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The entire coding region was replacd by a lacZ-neo cassette. The lacZ was under the control of the Purkinje cell-specific promoter. (J:71074)

Expression

In Mice Carrying this Mutation:

11 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Hes3 Mutation: 18 strains or lines available

References

• Original: J:71074 Hirata H, et al., Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain. EMBO J. 2001 Aug 15;20(16):4454-66
• All: 14 reference(s)