Tnfrsf10b^tm1Wnt
Targeted Allele Detail

Summary

• Symbol: Tnfrsf10b^tm1Wnt
• Name: tumor necrosis factor receptor superfamily, member 10b; targeted mutation 1, Astar Winoto
• MGI ID: MGI:3522001
• Synonyms: TRAIL-R^-
• Gene: Tnfrsf10b Location: Chr14:70004921-70021860 bp, + strand Genetic Position: Chr14, 36.1 cM
• Alliance: Tnfrsf10b^tm1Wnt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94681
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting construct was designed to replace a portion of exon 5, containing the transmembrane domain, and exon 6 with a neomycin resistance gene. RT-PCR of multiple tissues demonstrated a lack of transcript in mutant mice. (J:94681)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Tnfrsf10b Mutation: 29 strains or lines available

References

• Original: J:94681 Diehl GE, et al., TRAIL-R as a negative regulator of innate immune cell responses. Immunity. 2004 Dec;21(6):877-89
• All: 5 reference(s)