Cebpa^tm1Dgt
Targeted Allele Detail

Summary

• Symbol: Cebpa^tm1Dgt
• Name: CCAAT/enhancer binding protein alpha; targeted mutation 1, Daniel G Tenen
• MGI ID: MGI:3522010
• Synonyms: C/EBPalpha^F
• Gene: Cebpa Location: Chr7:34818718-34821353 bp, + strand Genetic Position: Chr7, 21.02 cM
• Alliance: Cebpa^tm1Dgt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94682
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank the single exon and a neo cassette inserted downstream of the exon. Western blot of whole-cell lysates of adult liver and total bone marrow cells showed that protein was present in mutants. (J:94682)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Cebpa Mutation: 18 strains or lines available

References

• Original: J:94682 Zhang P, et al., Enhancement of hematopoietic stem cell repopulating capacity and self-renewal in the absence of the transcription factor C/EBP alpha. Immunity. 2004 Dec;21(6):853-63
• All: 35 reference(s)