Stk17b^tm1Hed
Targeted Allele Detail

Summary

• Symbol: Stk17b^tm1Hed
• Name: serine/threonine kinase 17b (apoptosis-inducing); targeted mutation 1, Stephen Hedrick
• MGI ID: MGI:3522011
• Synonyms: Drak2^-
• Gene: Stk17b Location: Chr1:53794671-53824374 bp, - strand Genetic Position: Chr1, 26.99 cM
• Alliance: Stk17b^tm1Hed page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94685
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 400 bp fragment including the intron 2/exon 3 junction and most of exon 3 was replaced with a neo. Exon 3 contains the lysine residue required for ATP binding. Western blot of thymus and spleen from mutants confirmed a lack of protein. (J:94685)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Stk17b Mutation: 42 strains or lines available

References

• Original: J:94685 McGargill MA, et al., A deficiency in Drak2 results in a T cell hypersensitivity and an unexpected resistance to autoimmunity. Immunity. 2004 Dec;21(6):781-91
• All: 8 reference(s)