Nt5e^tm1Lft
Targeted Allele Detail

Summary

• Symbol: Nt5e^tm1Lft
• Name: 5' nucleotidase, ecto; targeted mutation 1, Linda F Thompson
• MGI ID: MGI:3522017
• Synonyms: Cd73^-, CD73-KO
• Gene: Nt5e Location: Chr9:88209662-88254142 bp, + strand Genetic Position: Chr9, 47.24 cM, cytoband E3.2
• Alliance: Nt5e^tm1Lft page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94697
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 3 was replaced with a neo cassette in reverse orientation to transcription. Northern blot of kidneys from mutant animlas indicated a lack of transcript. (J:94697)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Nt5e Mutation: 30 strains or lines available

References

• Original: J:94697 Thompson LF, et al., Crucial role for ecto-5'-nucleotidase (CD73) in vascular leakage during hypoxia. J Exp Med. 2004 Dec 6;200(11):1395-405
• All: 95 reference(s)