Cd209b^tm1Anjm
Targeted Allele Detail

Summary

• Symbol: Cd209b^tm1Anjm
• Name: CD209b antigen; targeted mutation 1, Andrew NJ McKenzie
• MGI ID: MGI:3522018
• Synonyms: SIGN-R1^-, SIGNR1^-
• Gene: Cd209b Location: Chr8:3967655-3976841 bp, - strand Genetic Position: Chr8, 1.92 cM, cytoband A1.2-A1.3
• Alliance: Cd209b^tm1Anjm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94698
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Sequences encoding amino acids 215-232 in exon 8 were replaced with a neomycin resistance gene. RNA transcripts were not detected in mutant spleen cells using RT-PCR. (J:94698)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Cd209b Mutation: 30 strains or lines available

References

• Original: J:94698 Lanoue A, et al., SIGN-R1 contributes to protection against lethal pneumococcal infection in mice. J Exp Med. 2004 Dec 6;200(11):1383-93
• All: 12 reference(s)