Ephb6^tm1Jwu
Targeted Allele Detail

Summary

• Symbol: Ephb6^tm1Jwu
• Name: Eph receptor B6; targeted mutation 1, Jiangping Wu
• MGI ID: MGI:3522020
• Synonyms: Eph6b^-
• Gene: Ephb6 Location: Chr6:41582416-41597443 bp, + strand Genetic Position: Chr6, 19.77 cM
• Alliance: Ephb6^tm1Jwu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94701
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A sequence from the ATG in exon 3 thru the 5' end of intron 4 ws replaced with a GFP-neo cassette. Mutants demonstrated no transcript expression but did express GFP driven by the endogenous promoter. (J:94701)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ephb6 Mutation: 54 strains or lines available

References

• Original: J:94701 Luo H, et al., EphB6-null mutation results in compromised T cell function. J Clin Invest. 2004 Dec;114(12):1762-73
• All: 5 reference(s)