Ptpn11^tm1Gsf
Targeted Allele Detail

Summary

• Symbol: Ptpn11^tm1Gsf
• Name: protein tyrosine phosphatase, non-receptor type 11; targeted mutation 1, Gen-Sheng Feng
• MGI ID: MGI:3522021
• Synonyms: Shp2^f, Shp2^flox, Shp2^loxp
• Gene: Ptpn11 Location: Chr5:121268596-121329460 bp, - strand Genetic Position: Chr5, 61.72 cM, cytoband F
• Alliance: Ptpn11^tm1Gsf page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94738
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank exon 4, which encodes amino acids 111-176. Deletion of the exon introduces a frameshift, creating a stop codon. (J:94738)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	27 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Ptpn11^tm1Gsf

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptpn11 Mutation: 46 strains or lines available

References

• Original: J:94738 Zhang EE, et al., Neuronal Shp2 tyrosine phosphatase controls energy balance and metabolism. Proc Natl Acad Sci U S A. 2004 Nov 9;101(45):16064-9
• All: 79 reference(s)