Trglyd^RR
QTL Variant Detail

Summary

• QTL variant: Trglyd^RR
• Name: triglycerides; RR
• MGI ID: MGI:3522044
• QTL: Trglyd Location: unknown Genetic Position: Chr1, cM position of peak correlated region/allele: 80.33 cM
• QTL Note: genome coordinates based on the marker associated with the peak LOD score

Variant origin

• Strain of Specimen: RR

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased plasma triglycerides compared to C57BL/6J. (J:94251)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94251

Linkage analysis was performed on 187 female (C57BL/6J x RR)F2 intercross animals to identify QTLs associated with plasma lipid traits. Parental strain RR exhibits increased body weight, plasma cholesterol and triglycerides compared to parental strain C57BL/6J. 80 microsatellite markers at an average spacing of 20 cM were used for the genome scan.

A locus associated with total plasma cholesterol, Cq6, mapped to distal mouse Chromosome 1 near D1Mit206 (LOD=16.3). This locus explains 33.1% of the phenotypic variance. The 95% confidence interval of Cq6 spans 87.2 cM - 97.8 cM. RR-derived alleles at Cq6 confer increased plasma cholesterol with dominant inheritance. Cq6 coincides with Cq2 but authors have chosen to keep the QTLs separate at present. A strongcandidate gene mapping near Cq6 is Apoa2 (92.6 cM). D1Mit206 also shows linkage to plasma triglycerides. The authors have designated a separate symbol, Trglyd, for this linkage. RR-derived alleles confer increased plasma triglycerides at Trglyd.

Suggestive linkage to plasma cholesterol mapped to 45 cM on mouse Chromosome 5 near D5Mit259 (LOD=2.6). Suggestive linkage to body weight mapped to 80 cM on mouse Chromosome 4 near D4Mit225 (LOD=3.8). RR-derived alleles confer decreased body weight at the chromosome 4 locus.

References

• Original: J:94251 Suto J, et al., Quantitative trait locus analysis of plasma cholesterol and triglyceride levels in C57BL/6J x RR F2 mice. Biochem Genet. 2004 Oct;42(9-10):347-63
• All: 1 reference(s)