Irf6^{Gt(OST398253)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Irf6^{Gt(OST398253)Lex}
• Name: interferon regulatory factor 6; gene trap OST398253, Lexicon Genetics
• MGI ID: MGI:3522096
• Synonyms: Irf6^gt1, Irf6^{Gt(VICTR48)1Bcsl}
• Gene: Irf6 Location: Chr1:192835419-192854331 bp, + strand Genetic Position: Chr1, 97.6 cM
• Alliance: Irf6^{Gt(OST398253)Lex} page

Mutation origin

• Mutant Cell Line: OST398253
• Germline Transmission: Earliest citation of germline transmission: J:94918
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The gene trap vector VICTR48 inserted into intron 1, 36 bp from the splice donor site. The vector contained flanking long terminal repeats, splice acceptor and donor sites, the ORF for neo, stop codons, polyA signal, the PGK promoter, marker fusion transcript and OmniBank sequence tag fusion transcript. Protein was not detected in mutants by Western blot. (J:46940)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  OST398253	CG647771 ; (MGI Seq Detail)	3' RACE	unknown
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  1 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Disease models

Expression

In Mice Carrying this Mutation:	54 assay results 2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	20 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Irf6 Mutation: 26 strains or lines available

Notes

This mutation is present in Lexicon Genomics' gene trap-mutated ES cell line OST398253. It was generated in an unspecified 129/Sv-derived ES cell line by random insertion of the VICTR48 gene trap vector.

References

• Original: J:94918 Schutte B, et al., Mice that lack Irf6 exhibit skin, limb and craniofacial abnormalities. MGI Direct Data Submission. 2005
• All: 20 reference(s)