Lhb^tm1Kmr
Targeted Allele Detail

Summary

• Symbol: Lhb^tm1Kmr
• Name: luteinizing hormone beta; targeted mutation 1, T Rajendra Kumar
• MGI ID: MGI:3522112
• Synonyms: Lhbeta^-
• Gene: Lhb Location: Chr7:45070370-45071278 bp, + strand Genetic Position: Chr7, 29.3 cM
• Alliance: Lhb^tm1Kmr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94719
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A sequence containing a floxed neo and 5 stop codons was inserted into exon 2, resulting in the disruption of protein translation. Immunofluorescence staining shows the lack of protein in sections of mutant pituitary. (J:94719)

Expression

In Structures Affected by this Mutation:

18 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lhb Mutation: 5 strains or lines available

References

• Original: J:94719 Ma X, et al., Targeted disruption of luteinizing hormone beta-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17294-9
• All: 7 reference(s)