Npr2^tm1Gar
Targeted Allele Detail

Summary

• Symbol: Npr2^tm1Gar
• Name: natriuretic peptide receptor 2; targeted mutation 1, David L Garbers
• MGI ID: MGI:3522129
• Synonyms: Npr2^-
• Gene: Npr2 Location: Chr4:43631935-43651244 bp, + strand Genetic Position: Chr4, 23.05 cM
• Alliance: Npr2^tm1Gar page

Skeletal comparison of wild type and Npr2^tm1Gar/Npr2^tm1Gar mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94718
• Parent Cell Line: SM1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 3-7, which encode the C-terminal half of the extracellular ligand-binding domain and the transmembrane segment, were replaced with a neo. mRNA was not detected in brains of mutant animals. (J:94718)

Expression

In Structures Affected by this Mutation:

13 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Npr2 Mutation: 63 strains or lines available

References

• Original: J:94718 Tamura N, et al., Critical roles of the guanylyl cyclase B receptor in endochondral ossification and development of female reproductive organs. Proc Natl Acad Sci U S A. 2004 Dec 7;101(49):17300-5
• All: 4 reference(s)