Tg(Tyrp1-TAg)3434Bee
Transgene Detail

Summary

• Symbol: Tg(Tyrp1-TAg)3434Bee
• Name: transgene insertion 3434, Friedrich Beermann
• MGI ID: MGI:3522144
• Synonyms: TRP-1/SV40 Tag, TRP-1/Tag, Tyrp1-Tag
• Transgene: Tg(Tyrp1-TAg)3434Bee Location: unknown
• Alliance: Tg(Tyrp1-TAg)3434Bee page

Transgene origin

• Strain of Origin: (BALB/c x C57BL/6J)F2

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: 1.4 kb of the Tyrosinase related protein 1 (Tyrp-1) promoter was fused to the SV40 Tag transforming sequences (including both small and large t antigens and the polyA tail. Approximately 8 copies of the transgene were inserted in the Y chromosome. Transgene expression was detected in the eye as early as E10.5. At 2-3 months of age, the SV40 large T antigen was strongly expressed in the eye, but only slightly in the skin of transgenic mice. No expression was detected in the kidney, liver, lung, spleen, or testis. Most mice were moribund by 3 months of age, primarily due to retinal tumors that had metastasized to the brain. (J:51324)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Tyrp1-TAg)3434Bee

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:51324 Penna D, et al., Tumors of the retinal pigment epithelium metastasize to inguinal lymph nodes and spleen in tyrosinase-related protein 1/SV40 T antigen transgenic mice. Oncogene. 1998 Nov 19;17(20):2601-7
• All: 6 reference(s)