Foxm1^tm1.1Rhc
Targeted Allele Detail

Summary

• Symbol: Foxm1^tm1.1Rhc
• Name: forkhead box M1; targeted mutation 1.1, Robert H Costa
• MGI ID: MGI:3522201
• Synonyms: Foxm1b^-
• Gene: Foxm1 Location: Chr6:128339957-128352849 bp, + strand Genetic Position: Chr6, 62.98 cM
• Alliance: Foxm1^tm1.1Rhc page

Foxm1^tm1.1Rhc/Foxm1^tm1.1Rhc embryonic lungs exhibit pulmonary artery hypertrophy

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94883
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: This allele is a derivative of Foxm1^tm1Rhc. The region flanked by loxP sites was deleted in the germline by mating mice carrying the floxed allele to mice carrying the Tg(EIIa-cre)C5379Lmgd transgene. Resulting chimeric mice were screened for offspring carrying an allele that was missing exons 4-7. RNase protection assays confirmed that no detectable transcript was expressed from this allele. (J:94883)

Expression

In Structures Affected by this Mutation:

15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Foxm1 Mutation: 28 strains or lines available

References

• Original: J:94883 Krupczak-Hollis K, et al., The mouse Forkhead Box m1 transcription factor is essential for hepatoblast mitosis and development of intrahepatic bile ducts and vessels during liver morphogenesis. Dev Biol. 2004 Dec 1;276(1):74-88
• All: 7 reference(s)