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CmcsDBA/2
QTL Variant Detail
Summary
QTL variant: CmcsDBA/2
Name: cerebral malaria susceptibility in CBA/N; DBA/2
MGI ID: MGI:3522315
QTL: Cmcs  Location: unknown  Genetic Position: Chr17, cM position of peak correlated region/allele: 17.98 cM
QTL Note: genome coordinates based on the marker associated with the peak LOD score
Variant
origin
Strain of Specimen:  DBA/2
Variant
description
Allele Type:    QTL
Mutation:    Undefined
    This allele confers resistance to P. berghei ANKA infection compared to CBA/N. (J:94127)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:94127

Linkage analysis was performed on a population of (CBA/N x DBA/2)F1 x CBA/N backcross animals to map QTLs associated with susceptibility to cerebral malaria. Parental strain CBA/N is susceptible to infection with Plasmodium berghei ANKA and die within 14days post-infection. Parental strain DBA/2 and (CBA/N x DBA/2)F1 hybrids are relatively resistant to P. berghei ANKA infection. 65 polymorphic markers covering 70% of the genome were used in the genome scan. Male backcross animals were infected with 1 x 10(6) P. berghei ANKA infected erythrocytes at 8-10 weeks of age.

A locus named Cmcs (cerebral malaria susceptibility in CBA/N) mapped to mouse Chromosome 17 near the H2 locus. Peak linkage occurs at 18.44 cM near D17Mit28 (P<0.0001). CBA/N-derived alleles confer susceptibility to P. berghei ANKA infection at Cmcs whereas DBA/2-derived alleles confer resistance. Candidate genes mapping near Cmcs include Tnf (19 cM), Lta (19 cM), H2-K, H2-Aa (18.65 cM), and H2-Ea (18.7 cM).

References
Original:  J:94127 Ohno T, et al., Detection of a new cerebral malaria susceptibility locus, using CBA mice. Immunogenetics. 2004 Dec;56(9):675-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory