Summary |
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Variant origin |
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Variant description |
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Phenotypes |
View phenotypes and curated references for all genotypes (concatenated display).
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Notes |
Mapping and Phenotype information for this QTL, its variants and associated markersJ:94127Linkage analysis was performed on a population of (CBA/N x DBA/2)F1 x CBA/N backcross animals to map QTLs associated with susceptibility to cerebral malaria. Parental strain CBA/N is susceptible to infection with Plasmodium berghei ANKA and die within 14days post-infection. Parental strain DBA/2 and (CBA/N x DBA/2)F1 hybrids are relatively resistant to P. berghei ANKA infection. 65 polymorphic markers covering 70% of the genome were used in the genome scan. Male backcross animals were infected with 1 x 10(6) P. berghei ANKA infected erythrocytes at 8-10 weeks of age. A locus named Cmcs (cerebral malaria susceptibility in CBA/N) mapped to mouse Chromosome 17 near the H2 locus. Peak linkage occurs at 18.44 cM near D17Mit28 (P<0.0001). CBA/N-derived alleles confer susceptibility to P. berghei ANKA infection at Cmcs whereas DBA/2-derived alleles confer resistance. Candidate genes mapping near Cmcs include Tnf (19 cM), Lta (19 cM), H2-K, H2-Aa (18.65 cM), and H2-Ea (18.7 cM). |
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References |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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