Ccr5^tm1Sush
Targeted Allele Detail

Summary

• Symbol: Ccr5^tm1Sush
• Name: C-C motif chemokine receptor 5; targeted mutation 1, Kouji Matsushima
• MGI ID: MGI:3522335
• Synonyms: Ccr5^-
• Gene: Ccr5 Location: Chr9:123921557-123934153 bp, + strand Genetic Position: Chr9, 75.05 cM, cytoband F
• Alliance: Ccr5^tm1Sush page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94937
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was replaced by a neomycin resistance gene. RT-PCR comfirmed the lack of transcript in mutant lymphocytes. (J:94937)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccr5 Mutation: 31 strains or lines available

References

• Original: J:94937 Murai M, et al., Peyer's patch is the essential site in initiating murine acute and lethal graft-versus-host reaction. Nat Immunol. 2003 Feb;4(2):154-60
• All: 22 reference(s)