Lgals3bp^tm1Megt
Targeted Allele Detail

Summary

• Symbol: Lgals3bp^tm1Megt
• Name: lectin, galactoside-binding, soluble, 3 binding protein; targeted mutation 1, Meg Trahey
• MGI ID: MGI:3522338
• Synonyms: CyCAP^-
• Gene: Lgals3bp Location: Chr11:118283573-118292787 bp, - strand Genetic Position: Chr11, 83.14 cM, cytoband E
• Alliance: Lgals3bp^tm1Megt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94936
• Parent Cell Line: E14.1a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance gene replaced exons 3-6, leaving only the coding sequence for the first 27 amino acids. Northern blot of total RNA from kidney and liver of mutant mice showed that no transcript was present. (J:94936)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lgals3bp Mutation: 31 strains or lines available

References

• Original: J:94936 Trahey M, et al., Cyclophilin C-associated protein: a normal secreted glycoprotein that down-modulates endotoxin and proinflammatory responses in vivo. Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):3006-11
• All: 2 reference(s)