Clcn1^adr-mto6J
Chemically induced Allele Detail

Summary

• Symbol: Clcn1^adr-mto6J
• Name: chloride channel, voltage-sensitive 1; myotonia 6 Jackson
• MGI ID: MGI:3522441
• Synonyms: Clcn1^nmf310, neuroscience mutagenesis facility 310, nmf310, NMF310
• Gene: Clcn1 Location: Chr6:42263619-42292690 bp, + strand Genetic Position: Chr6, 20.57 cM
• Alliance: Clcn1^adr-mto6J page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Undefined
• Mutation details: Complementation tests between NMF310 and Clcn1^adr-mto were conducted. The results of heterozygous x heterozygous matings (NMF310 x BALB/cByj-Clcn1^adr-mto2J), i.e. 6 affected mice in a total of 29 progeny, suggest that NMF310 represents an allele of Clcn1.
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clcn1 Mutation: 71 strains or lines available

Notes

The hind limbs of these mutants appear to lose function intermittently, i.e. both or one or the other hind leg may lag behind, or may be stretched to the side or front during movement. These episodes usually last less than a minute, and the mice then move around quite normally. Front limbs appear to be affected to a lesser degree. When the mutants are lifted up by their tail, the hind legs come together and point down- or backwards. The mutants do not breed and the colony has to be maintained through ovarian transplants.

References

• Original: J:87349 JAX Neuroscience Mutagenesis Facility, Heritable mouse mutants from JAX NMF ENU Mutagenesis Program. MGI Direct Data Submission. 2004-7
• All: 1 reference(s)