Cdh2^tm1Glr
Targeted Allele Detail

Summary

• Symbol: Cdh2^tm1Glr
• Name: cadherin 2; targeted mutation 1, Glenn L Radice
• MGI ID: MGI:3522469
• Synonyms: Ncad^fl, N-cad^flox
• Gene: Cdh2 Location: Chr18:16721934-16942303 bp, - strand Genetic Position: Chr18, 10.1 cM
• Alliance: Cdh2^tm1Glr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:98828
• Parent Cell Line: TL1/TL-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: Exon 1, which contains the translational start site and upstream transcriptional regulatory sequences, was flanked with loxP sites. An FRT-flanked neomycin selection cassette was inserted into intron 1 and subsequently removed by crossing with mice expressing FLP recombinase in the germline. (J:98828)

Expression

In Mice Carrying this Mutation:	147 assay results
In Structures Affected by this Mutation:	10 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cdh2 Mutation: 51 strains or lines available

References

• Original: J:98828 Kostetskii I, et al., Induced deletion of the N-cadherin gene in the heart leads to dissolution of the intercalated disc structure. Circ Res. 2005 Feb 18;96(3):346-54
• All: 59 reference(s)