Als2^tm1Cai
Targeted Allele Detail

Summary

• Symbol: Als2^tm1Cai
• Name: alsin Rho guanine nucleotide exchange factor; targeted mutation 1, Huaibin Cai
• MGI ID: MGI:3522476
• Synonyms: ALS2^-
• Gene: Als2 Location: Chr1:59202085-59276390 bp, - strand Genetic Position: Chr1, 29.33 cM
• Alliance: Als2^tm1Cai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:100336
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 39 bp BamHI fragment in the 1st coding exon of ALS2 was replaced with a lacZ gene and selection marker flanked with loxP sites. QPCR and Western blot analysis confirmed the absence of transcription and translation. (J:100336)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Als2 Mutation: 88 strains or lines available

References

• Original: J:100336 Cai H, et al., Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress. J Neurosci. 2005 Aug 17;25(33):7567-74
• All: 4 reference(s)