Park7^tm1Cai
Targeted Allele Detail

Summary

• Symbol: Park7^tm1Cai
• Name: Parkinson disease (autosomal recessive, early onset) 7; targeted mutation 1, Hubaibin Cai
• MGI ID: MGI:3522482
• Gene: Park7 Location: Chr4:150981590-150994378 bp, - strand Genetic Position: Chr4, 81.52 cM, cytoband E1
• Alliance: Park7^tm1Cai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:141628
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The first coding exon was replaced with a selection marker flanked with loxp sites. QPCR and Western blot analysis confirmed the absence of gene products. (J:141628)

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Park7 Mutation: 56 strains or lines available

References

• Original: J:141628 Chandran JS, et al., Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiol Dis. 2008 Mar;29(3):505-14
• All: 6 reference(s)