Dctn1^tm1Cai
Targeted Allele Detail

Summary

• Symbol: Dctn1^tm1Cai
• Name: dynactin 1; targeted mutation 1, Huaibin Cai
• MGI ID: MGI:3522484
• Synonyms: Dctn1^m
• Gene: Dctn1 Location: Chr6:83142902-83177099 bp, + strand Genetic Position: Chr6, 35.94 cM
• Alliance: Dctn1^tm1Cai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:129269
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Nucleotide substitutions (GGGC to CTGA) in exon 2 introduced an amino acid substitution of a serine for a glycine at position 59 (G59S). A loxP site was inserted into intron 1 and a floxed neo cassette was also inserted into intron 3 and subsequently removed by cre-mediated recombination. (J:129269)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dctn1 Mutation: 65 strains or lines available

References

• Original: J:129269 Lai C, et al., The G59S mutation in p150(glued) causes dysfunction of dynactin in mice. J Neurosci. 2007 Dec 19;27(51):13982-90
• All: 1 reference(s)