Ovol2^tm1Xdai
Targeted Allele Detail

Summary

• Symbol: Ovol2^tm1Xdai
• Name: ovo like zinc finger 2; targeted mutation 1, Xing Dai
• MGI ID: MGI:3522498
• Gene: Ovol2 Location: Chr2:144147095-144174000 bp, - strand Genetic Position: Chr2, 70.99 cM, cytoband H1
• Alliance: Ovol2^tm1Xdai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:106405
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exons 1a, 1b and 2 were replaced with a cassette containing an EGFP and a PGK-neo cassette so that EGFP expression would be controled by the endogenous promoter region. EGFP expression was detected in the inner cell mass of blastocysts and later in the epiblast but not the extraembryonic region of E6.5 embryos. (J:106405)

Expression

In Mice Carrying this Mutation:	80 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ovol2 Mutation: 22 strains or lines available

References

• Original: J:106405 Mackay DR, et al., The mouse Ovol2 gene is required for cranial neural tube development. Dev Biol. 2006 Mar 1;291(1):38-52
• All: 1 reference(s)