Tg(RBP3-TAg)#Ove
Transgene Detail

Summary

• Symbol: Tg(RBP3-TAg)#Ove
• Name: transgene insertion, Paul A Overbeek
• MGI ID: MGI:3522638
• Synonyms: IRBP-TAg, IT2
• Transgene: Tg(RBP3-TAg)#Ove Location: unknown
• Alliance: Tg(RBP3-TAg)#Ove page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A 1.3 kb fragment of the human RBP3 gene including promoter and transcription start site was used to direct expression of the SV40 T antigen and polyA sequences. (J:59267)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(RBP3-TAg)#Ove

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

Notes

This mutation is representative of 4 transgenic founders (413, 414, 417, 437) carrying 2-9 copies of the trangene. All founders exhibit brain and eye tumors at a high incidence of 63%-100%.

References

• Original: J:59267 al-Ubaidi MR, et al., Bilateral retinal and brain tumors in transgenic mice expressing simian virus 40 large T antigen under control of the human interphotoreceptor retinoid-binding protein promoter. J Cell Biol. 1992 Dec;119(6):1681-7
• All: 3 reference(s)