Tg(Upk2-HRAS*Q61L)12Xrw
Transgene Detail

Summary

• Symbol: Tg(Upk2-HRAS*Q61L)12Xrw
• Name: transgene insertion 12, Xue-Ru Wu
• MGI ID: MGI:3522718
• Synonyms: UPII/Ha-ras 12
• Transgene: Tg(Upk2-HRAS*Q61L)12Xrw Location: unknown
• Alliance: Tg(Upk2-HRAS*Q61L)12Xrw page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Upk2-HRAS*Q61L)12Xrw expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  rabbit, European	Hras (127486605)	Transgene codes for a protein with a glutamine to leucine mutation.

• Mutation details: This transgene included a 3.6 kb fragment encoding the murine Upk2 gene promoter placed upstream of a 3.0 kb sequence encoding a mutant rabbit Hras gene (glutamine to leucine point mutation at codon 61). Mice carrying this allele generated 2 transgene fragments measuring 4.9 and 8.2 kb in length, representing head to tail and tail to tail arrangements, respectively. Approximately 30 copies of the transgene were inserted into the genome. (J:69251)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:69251 Zhang ZT, et al., Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation. Oncogene. 2001 Apr 12;20(16):1973-80
• All: 3 reference(s)