Arigg10^BALB/cByJ
QTL Variant Detail

Summary

• QTL variant: Arigg10^BALB/cByJ
• Name: anti-RBC IgG antibodies 10; BALB/cByJ
• MGI ID: MGI:3524946
• QTL: Arigg10 Location: unknown Genetic Position: Chr16, Syntenic

Variant origin

• Strain of Specimen: BALB/cByJ

Variant description

• Allele Type: QTL
• Mutation: Undefined
• This allele confers increased anti-RBC IgG antibodies at 8 months of age compared to NZB/BlNJ. (J:93737)

Notes

Mapping and Phenotype information for this QTL, its variants and associated markers

J:93737

Linkage analysis was performed on 222 female animals from a (NZB/BlNJ x BALB/cByJ)F2 intercross to identify QTLs associated with susceptibility to autoimmune hemolytic anemia (AHA) and systemic lupus erythematosus (SLE). 96 polymorphic markers at an average spacing of 17 cM were used in the genome scan. Parental strain NZB/BlNJ is susceptible to autoimmune hemolytic anemia and exhibits elevated serum levels of anti-red blood cell antibodies compared to BALB/cByJ. NZB/BlNJ is also susceptible to systemic lupus erythematosus and exhibits elevated serum levels of antinuclear antibodies compared to parental strain BALB/cByJ.

Linkage to anti-red blood cell IgG antibodies at 8 months of age mapped to 54 cM on mouse Chromosome 16 (P=5.0 x 10-3). This locus is named Arigg10 (anti-RBC IgG antibodies 10). BALB/cByJ-derived alleles confer increased IgG antibodies at this locus.

References

• Original: J:93737 Lee NJ, et al., Multiple loci are linked with anti-red blood cell antibody production in NZB mice -- comparison with other phenotypes implies complex modes of action. Clin Exp Immunol. 2004 Oct;138(1):39-46
• All: 1 reference(s)