Prkce^tm1Bai
Targeted Allele Detail

Summary

• Symbol: Prkce^tm1Bai
• Name: protein kinase C, epsilon; targeted mutation 1, Gottfried Baier
• MGI ID: MGI:3524969
• Synonyms: PKCepsilon^-
• Gene: Prkce Location: Chr17:86475213-86965347 bp, + strand Genetic Position: Chr17, 56.74 cM
• Alliance: Prkce^tm1Bai page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94663
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene was inserted into exon 1. Immunostaining confirmed the lack of protein in mutant thymocytes. Flow cytometry indicated that thymocyte numbers and development appeared to be unaffected by the mutation.

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkce Mutation: 40 strains or lines available

References

• Original: J:94663 Gruber T, et al., Protein kinase Cvarepsilon is dispensable for TCR/CD3-signaling. Mol Immunol. 2005 Feb;42(3):305-310
• All: 2 reference(s)