Itgb4^tm2Fgg
Targeted Allele Detail

Summary

• Symbol: Itgb4^tm2Fgg
• Name: integrin beta 4; targeted mutation 2, Filippo G Giancotti
• MGI ID: MGI:3524974
• Synonyms: beta4-1355T, beta4^1355T, Itgb4^-
• Gene: Itgb4 Location: Chr11:115865556-115899238 bp, + strand Genetic Position: Chr11, 80.91 cM
• Alliance: Itgb4^tm2Fgg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94627
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Sequence coding for the Itgb4 cytoplasmic domain up to amino acid 1355, a stop codon, SV40 pA signal sequences, and a neomycin resistance gene cassette were inserted immediately downstream of the exon encoding the transmembrane segment of the protein. Immunoprecipitation and FACS analysis on primary keratinocytes indicated that the mutant protein is expressed at the cell surface. (J:94627)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Itgb4 Mutation: 107 strains or lines available

References

• Original: J:94627 Nikolopoulos SN, et al., Integrin beta4 signaling promotes tumor angiogenesis. Cancer Cell. 2004 Nov;6(5):471-83
• All: 6 reference(s)