Tg(Gh-Gal)4599Vron
Transgene Detail

Summary

• Symbol: Tg(Gh-Gal)4599Vron
• Name: transgene insertion 4599, M E Vrontakis
• MGI ID: MGI:3524994
• Synonyms: galanin, GAL-Tg, Tg(Gh-Gal)#Vron
• Transgene: Tg(Gh-Gal)4599Vron Location: unknown
• Alliance: Tg(Gh-Gal)4599Vron page

Transgene origin

• Strain of Origin: C57BL/6 or SJL

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Gh-Gal)4599Vron expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  rat

  Gal (29141)

  Gal	(MGI:95637)

• Mutation details: The rat preprogalanin full length cDNA, including the polyA tail was cloned downstream of a 320 bp fragment containing the rat Gh promoter. Transgene expression was observed in the pituitary, but was not observed in the ovary, testis, spleen, liver or fat. (J:86486)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tg(Gh-Gal)4599Vron

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:86486 Perumal P, et al., Transgenic mice over-expressing galanin exhibit pituitary adenomas and increased secretion of galanin, prolactin and growth hormone. J Endocrinol. 2003 Nov;179(2):145-54
• All: 5 reference(s)