Irag1^tm1Jens
Targeted Allele Detail

Summary

• Symbol: Irag1^tm1Jens
• Name: inositol 1,4,5-triphosphate receptor associated 1; targeted mutation 1, Jens Schlossmann
• MGI ID: MGI:3525059
• Synonyms: Irag^delta12
• Gene: Irag1 Location: Chr7:110467473-110581668 bp, - strand Genetic Position: Chr7, 57.9 cM
• Alliance: Irag1^tm1Jens page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94387
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 12 encodes the amino-terminal part of the coiled-coil domain, and was deleted upon Cre expression from a Cre-deleter mouse. Western blot showed the presence of a smaller protein than wild-type in mutant stomach samples, corresponding to the loss of exon 12 coding sequence. (J:94387)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Irag1 Mutation: 51 strains or lines available

References

• Original: J:94387 Geiselhoringer A, et al., IRAG is essential for relaxation of receptor-triggered smooth muscle contraction by cGMP kinase. EMBO J. 2004 Oct 27;23(21):4222-31
• All: 1 reference(s)