Hdac4^tm1Eno
Targeted Allele Detail

Summary

• Symbol: Hdac4^tm1Eno
• Name: histone deacetylase 4; targeted mutation 1, Eric N Olson
• MGI ID: MGI:3525071
• Synonyms: HDAC4^-
• Gene: Hdac4 Location: Chr1:91856501-92123421 bp, - strand Genetic Position: Chr1, 46.24 cM
• Alliance: Hdac4^tm1Eno page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94631
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 6 was replaced upon the insertion of an nLacZ-neo cassette in frame with amino acid 162. The deleted region encodes the nuclear localization sequence and the complete deacetylase catalytic domain. Mutant heart and brain samples demonstrated a lack of wild-type mRNA by RT-PCR analysis. (J:94631)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hdac4 Mutation: 112 strains or lines available

References

• Original: J:94631 Vega RB, et al., Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell. 2004 Nov 12;119(4):555-66
• All: 11 reference(s)