Tg(CAG-WRN*K577M)5025Wcl
Transgene Detail

Summary

• Symbol: Tg(CAG-WRN*K577M)5025Wcl
• Name: transgene insertion 5025, Warren C Ladiges
• MGI ID: MGI:3525073
• Synonyms: K577-WRN, Tg(ACTB-WRN*K577M)5025Wcl, Tg(CAG-WRN*K577M)5025Wcl
• Transgene: Tg(CAG-WRN*K577M)5025Wcl Location: unknown
• Alliance: Tg(CAG-WRN*K577M)5025Wcl page

Transgene origin

• Strain of Origin: C57BL/6 x C3H

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CAG-WRN*K577M)5025Wcl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  WRN (7486)

  Wrn	(MGI:109635)

  Transgene codes for a protein with a lysine to methionine mutation.

• Mutation details: The transgene is composed of a full length cDNA encoding human WRN with a mutation that alters lysine 577 to methionine expressed under the control of a cytomegalovirus enhancer and a chicken beta-actin promoter, and was followed by a rabbit beta-globin polyadenylation site. (J:95127)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

Notes

This line is representative of three lines made, which include the 4128, 4998 and the 5025 lines.

References

• Original: J:95127 Wang L, et al., Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene. Genetics. 2000 Jan;154(1):357-62
• All: 2 reference(s)