Abca1^tm1Blt
Targeted Allele Detail

Summary

• Symbol: Abca1^tm1Blt
• Name: ATP-binding cassette, sub-family A member 1; targeted mutation 1, Horst Bluethmann
• MGI ID: MGI:3525100
• Gene: Abca1 Location: Chr4:53030787-53159895 bp, - strand Genetic Position: Chr4, 28.57 cM, cytoband A5-B3
• Alliance: Abca1^tm1Blt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95088
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Insertion of a neomycin resistance cassette into exon 2 disrupted the gene. (J:95088)

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Abca1 Mutation: 90 strains or lines available

References

• Original: J:95088 Nofer JR, et al., Impaired platelet activation in familial high density lipoprotein deficiency (Tangier disease). J Biol Chem. 2004 Aug 6;279(32):34032-7
• All: 1 reference(s)