Tg(Dct-Grm1)ESzc
Transgene Detail

Summary

• Symbol: Tg(Dct-Grm1)ESzc
• Name: transgene insertion E, Suzie Chen
• MGI ID: MGI:3525118
• Synonyms: Tg(Grm1)EPv
• Transgene: Tg(Dct-Grm1)ESzc Location: unknown
• Alliance: Tg(Dct-Grm1)ESzc page

Transgene origin

• Strain of Origin: C57BL/6J

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Dct-Grm1)ESzc expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Grm1 (MGI:1351338)

• Mutation details: The promoter from the mouse Dct gene (-3181 to + 445) drove the expression of the mouse Grm1 coding sequence corresponsing to -105 to + 4164. The polyA tail in the construct was from the human GH gene. Strong transgene expression was detected in mice carrying this allele. (J:83183)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:83183 Pollock PM, et al., Melanoma mouse model implicates metabotropic glutamate signaling in melanocytic neoplasia. Nat Genet. 2003 May;34(1):108-12
• All: 9 reference(s)