Nkx2-1^tm1Rdl
Targeted Allele Detail

Summary

• Symbol: Nkx2-1^tm1Rdl
• Name: NK2 homeobox 1; targeted mutation 1, Roberto Di Lauro
• MGI ID: MGI:3525207
• Synonyms: Titf1^Foxe1
• Gene: Nkx2-1 Location: Chr12:56578741-56583570 bp, - strand Genetic Position: Chr12, 24.42 cM, cytoband C1-C3
• Alliance: Nkx2-1^tm1Rdl page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95017
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A sequence from rat Foxe1 replaced the endogenous sequence spanning from the start site to the end of the homeobox (nucleotide positions 7957 to 9480). Sv40 pA was added after the stop codon, as well as a PGK-neo cassette. The inserted sequence was ectopically expressed in Titf1 expression domains like the lung and diencephalons, (J:95017)

Expression

In Mice Carrying this Mutation:

5 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nkx2-1 Mutation: 24 strains or lines available

References

• Original: J:95017 Parlato R, et al., An integrated regulatory network controlling survival and migration in thyroid organogenesis. Dev Biol. 2004 Dec 15;276(2):464-75
• All: 2 reference(s)