Cxcr4^tm2Yzo
Targeted Allele Detail

Summary

• Symbol: Cxcr4^tm2Yzo
• Name: C-X-C motif chemokine receptor 4; targeted mutation 2, Yong-Rui Zou
• MGI ID: MGI:3525214
• Synonyms: Cxcr4^f, Cxcr4^loxP
• Gene: Cxcr4 Location: Chr1:128515936-128520030 bp, - strand Genetic Position: Chr1, 56.43 cM
• Alliance: Cxcr4^tm2Yzo page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94911
• Parent Cell Line: E14 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A neomycin resistance gene flanked by loxP sites was inserted into intron 1 and a third loxP site was introduced into exon 2. Crossing with EIIa-cre mice resulted in the excision of the neo, leaving exon 2 flanked with loxP sites. (J:94911)

Disease models

Expression

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Cxcr4^tm2Yzo

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cxcr4 Mutation: 46 strains or lines available

References

• Original: J:94911 Nie Y, et al., The role of CXCR4 in maintaining peripheral B cell compartments and humoral immunity. J Exp Med. 2004 Nov 1;200(9):1145-56
• All: 94 reference(s)