Pf4^tm1Mako
Targeted Allele Detail

Summary

• Symbol: Pf4^tm1Mako
• Name: platelet factor 4; targeted mutation 1, M Anna Kowalska
• MGI ID: MGI:3525230
• Synonyms: mPF4^-
• Gene: Pf4 Location: Chr5:90920362-90921242 bp, + strand Genetic Position: Chr5, 44.78 cM
• Alliance: Pf4^tm1Mako page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:94900
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: All three exons were replaced with a neomycin resistance gene. RT-PCR and immunoblot confirmed the lack of transcript and protein, respectively, from mutant plateles. (J:94900)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pf4 Mutation: 16 strains or lines available

Notes

ES Cell Line = 129/SvJ ES cells, GENOMESYSTEMS, Inc

References

• Original: J:94900 Eslin DE, et al., Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: dissociation between anticoagulant and antithrombotic effect of heparin. Blood. 2004 Nov 15;104(10):3173-80
• All: 31 reference(s)