Erbb2^{tm8(Erbb2)Mul}
Targeted Allele Detail

Summary

• Symbol: Erbb2^{tm8(Erbb2)Mul}
• Name: erb-b2 receptor tyrosine kinase 2; targeted mutation 8, William J Muller
• MGI ID: MGI:3525444
• Synonyms: ErbB2^KI, Flneo NeuNT, NeuNT, neuNT^ki
• Gene: Erbb2 Location: Chr11:98303310-98328542 bp, + strand Genetic Position: Chr11, 61.75 cM, cytoband D
• Alliance: Erbb2^{tm8(Erbb2)Mul} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:61202
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, Inserted expressed sequence)
• Mutations: Insertion, Intragenic deletion
• Erbb2^{tm8(Erbb2)Mul} expresses 1 gene
  Knock-in expresses:
  

  Organism	Expressed Gene	Note
  mouse	Erbb2 (MGI:95410)

• Mutation details: Exon 1 of the endogenous Erbb2 allele was replaced by a lox-P flanked PGK-neomycin-HSV polyA cassette, followed by an oncogenic Erbb2 cDNA containing an activating point mutation in the transmembrane domain. (J:61202)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Erbb2^{tm8(Erbb2)Mul}

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Erbb2 Mutation: 61 strains or lines available

References

• Original: J:61202 Andrechek ER, et al., Amplification of the neu/erbB-2 oncogene in a mouse model of mammary tumorigenesis. Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3444-9
• All: 21 reference(s)