Afdn^tm1Mrcr
Targeted Allele Detail

Summary

• Symbol: Afdn^tm1Mrcr
• Name: afadin, adherens junction formation factor; targeted mutation 1, John A Mercer
• MGI ID: MGI:3525467
• Synonyms: Af6^-
• Gene: Afdn Location: Chr17:13980735-14126059 bp, + strand Genetic Position: Chr17, 8.95 cM, cytoband A2
• Alliance: Afdn^tm1Mrcr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:57046
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neomycin cassette was inserted into exon 4. Absence of protein product was confirmed by immunohistochemistry and Western blot analysis. (J:57046)

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Afdn Mutation: 84 strains or lines available

References

• Original: J:57046 Zhadanov AB, et al., Absence of the tight junctional protein AF-6 disrupts epithelial cell-cell junctions and cell polarity during mouse development. Curr Biol. 1999 Aug 26;9(16):880-8
• All: 1 reference(s)