Mapk14^tm1.2Otsu
Targeted Allele Detail

Summary

• Symbol: Mapk14^tm1.2Otsu
• Name: mitogen-activated protein kinase 14; targeted mutation 1.2, Kinya Otsu
• MGI ID: MGI:3525576
• Synonyms: p38alpha^flox
• Gene: Mapk14 Location: Chr17:28910316-28967379 bp, + strand Genetic Position: Chr17, 14.85 cM
• Alliance: Mapk14^tm1.2Otsu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:95116
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: LoxP sites were inserted to flank the exon encoding part of the catalytic domain and the ATP binding loop (amino acids 40-83). (J:95116)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mapk14 Mutation: 43 strains or lines available

References

• Original: J:95116 Nishida K, et al., p38alpha mitogen-activated protein kinase plays a critical role in cardiomyocyte survival but not in cardiac hypertrophic growth in response to pressure overload. Mol Cell Biol. 2004 Dec;24(24):10611-20
• All: 51 reference(s)