Hoxd9^tm1Mrc
Targeted Allele Detail

Summary

• Symbol: Hoxd9^tm1Mrc
• Name: homeobox D9; targeted mutation 1, Mario Capecchi
• MGI ID: MGI:3525581
• Gene: Hoxd9 Location: Chr2:74528107-74530552 bp, + strand Genetic Position: Chr2, 44.13 cM
• Alliance: Hoxd9^tm1Mrc page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:52279
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: An MC1 neomycin Poly(A) cassette was inserted into the sequences encoding the homeobox domain. The resulting protein is unable to bind protein. (J:52279)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hoxd9 Mutation: 16 strains or lines available

References

• Original: J:52279 Chen F, et al., Paralogous mouse Hox genes, Hoxa9, Hoxb9, and Hoxd9, function together to control development of the mammary gland in response to pregnancy. Proc Natl Acad Sci U S A. 1999 Jan 19;96(2):541-6
• All: 4 reference(s)